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Ferroptosis inducers can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death (Li et al., 2020)

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Combination-pathway research: Commonly studied with GLP-1 receptor agonists (e.g., semaglutide) to evaluate multi-hormone effects on appetite and metabolism

Mass spectrometric characterization of protein adducts of multiple P450-dependent reactive intermediates of diclofenac to human glutathione-S-transferase P1-1